Post a job

Senior Scientist Oligonucleotide Chemistry

Dyne Therapeutics

πŸ‡ΊπŸ‡Έ United States
Base Salary
40k-80k USD (est.)
Dyne Therapeutics

Job Description

Role Summary:

As a member of the Platform Oligo innovation team, the successful candidate will contribute to the development of Dyne’s oligonucleotide chemistry platform and enable the discovery of novel oligonucleotide therapeutics. This individual will be responsible for building an internal oligonucleotide chemistry lab and will lead the design, synthesis, purification, and analysis of oligonucleotides and their conjugates. The position requires a combination of deep technical expertise in oligonucleotide synthesis and in-depth knowledge of oligonucleotides as a therapeutic modality.

This role is based in Waltham, MA without the possibility of being a remote role. Applicants must be able to relocate to the area.

Primary Responsibilities Include:

  • Independently perform solid phase synthesis of oligonucleotides with diverse sugar and backbone modifications at various scales

  • Troubleshoot and optimize synthesis methods to produce high quality oligonucleotides of various lengths

  • Perform purification (anion exchange, reverse phase), analysis (HPLC/UPLC), characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates

  • Explore novel chemistries and designs to improve the DMPK and safety properties of oligonucleotides

  • Manage hit-to-lead optimization process and deliverables

  • Interact with the biology and preclinical groups to deliver clinical candidates

  • Multi-task across several projects and manage time effectively to achieve results

  • Collect, present, and discuss data at internal team meetings

Education and Skills Requirements:

  • PhD in chemistry or related discipline with a minimum of 4 years of experience in oligonucleotide synthesis -prior postdoctoral experience is preferred- or MSc with at least 7 years of industrial experience in the biotechnology industry

  • Strong experience with the operation of oligonucleotide synthesis machinery (Mermade), and AKTA purification unit

  • Working knowledge of RNA biology to enable collaboration across functions

  • Experience with ASO, siRNA or other DNA/RNA targeting modalities

  • Experience in nucleoside chemistry and bioconjugation are a plus


Salary and compensation

                                                                                                        No salary data published by company so we estimated salary based on similar jobs related to Senior and Senior jobs that are similar:

                                                                                                                                                             $40,000 β€” $80,000/year



                                                πŸ’° 401(k)

🌎 Distributed team

⏰ Async

πŸ€“ Vision insurance

🦷 Dental insurance

πŸš‘ Medical insurance

πŸ– Unlimited vacation

πŸ– Paid time off

πŸ“† 4 day workweek

πŸ’° 401k matching

πŸ” Company retreats

🏬 Coworking budget

πŸ“š Learning budget

πŸ’ͺ Free gym membership

🧘 Mental wellness budget

πŸ–₯ Home office budget

πŸ₯§ Pay in crypto

πŸ₯Έ Pseudonymous

πŸ’° Profit sharing

πŸ’° Equity compensation

⬜️ No whiteboard interview

πŸ‘€ No monitoring system

🚫 No politics at work

πŸŽ… We hire old (and young)


Waltham, Massachusetts, United States

Advice from our career coach

Hey there! We're looking for a rockstar to join our Platform Oligo innovation team at Dyne. As a member of the team, you'll play a crucial role in developing our oligonucleotide chemistry platform and helping us discover new therapeutics. Your main responsibilities will include synthesizing and analyzing oligonucleotides, managing the optimization process, and collaborating with other teams. We need someone with deep expertise in oligonucleotide synthesis and knowledge of oligonucleotides as a therapeutic modality. This is an onsite role in Waltham, MA, so no remote work. If you're up for the challenge, we'd love to hear from you!

Apply for this job


Please let Dyne Therapeutics know you found this job with This helps us grow!

About the job

Feb 8, 2024


40k-80k USD (est.)

πŸ‡ΊπŸ‡Έ United States mascot